3. Hcy
11 μελέτες αναφέρουν ότι ένα σημαντικό ποσοστό ασθενών με ομαλό λειχήνα δέρματος και στόματος έχουν ασυνήθιστα υψηλά επίπεδα ομοκυστεΐνης στο αίμα.
Επίσης, ίσως υπάρχει στενή σχέση και στην σοβαρότητα της νόσου διότι μία μελέτη ανέφερε ότι όσο υψηλότερα ήταν τα επίπεδα της ομο, τόσο πιο σοβαρότερη η νόσος.
Serum homocysteine could be reliable predictors of subclinical atherosclerosis in LP (, besides b12 def)
Hcy
Α. ΑΣΥΝΗΘΙΣΤΑ ΥΨΗΛΑ: ομαλός λειχήνας δέρματος, ομαλός λειχηνας στόματος, (6+5=11)
Lichen planus (6)
1. 2014
Serum homocysteine were significantly higher in lichen planus patients than controls (P < 0.001).
Saleh N, Samir N, Megahed H, Farid E. Homocysteine and other cardiovascular risk factors in patients with lichen planus. J Eur Acad Dermatol Venereol. 2014 Nov;28(11):1507-13. doi: 10.1111/jdv.12329. Epub 2013 Dec 12. PMID: 24330130.
https://pubmed.ncbi.nlm.nih.gov/24330130/
2. 2017
This hospital-based case-control study included 110 patients with LP: 70 with cutaneous LP (CLP) and 40 with oral LP (OLP).
There were significantly higher prevalence of higher Hcy, among patients' groups.
Rashed L, Abdel Hay R, AlKaffas M, Ali S, Kadry D, Abdallah S. Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus. J Oral Pathol Med. 2017 Nov;46(10):1023-1029. doi: 10.1111/jop.12588. Epub 2017 May 25. PMID: 28463405.
https://pubmed.ncbi.nlm.nih.gov/28463405/
3. 2019
Significantly increased blood plasma levels of HC,
Melnyk TV, Bondar SA. The role of homocysteine and other endogenous intoxication markers in the pathogenesis of lichen planus. Arch Balk Med Union. 2019;54(3):503-507
https://umbalk.org/the-role-of-homocysteine-and-other-endogenous-intoxication-markers-in-the-pathogenesis-of-lichen-planus/
4. a positive correlation was observed between lichen planus and increased serum homocysteine levels.
Nasiri S, Sadeghzadeh-Bazargan A, Robati RM, Haghighatkhah HR, Younespour S. Subclinical atherosclerosis and cardiovascular markers in patients with lichen planus: A case–control study. Indian J Dermatol Venereol Leprol 2019;85:138-144
https://ijdvl.com/subclinical-atherosclerosis-and-cardiovascular-markers-in-patients-with-lichen-planus-a-case-control-study/
https://pubmed.ncbi.nlm.nih.gov/30632483/
5. 2020
High homocysteine levels in lichen planus play a significant role in modifying the arteries and leading to their dysfunction
Balani P, Lopez A R, Nobleza C N, et al. (December 30, 2020) Can Pioglitazone Safeguard Patients of Lichen Planus Against Homocysteine Induced Accelerated Cardiovascular Aging and Reduced Myocardial Performance: A Systematic Review. Cureus 12(12): e12372. doi:10.7759/cureus.12372
https://www.cureus.com/articles/45427-can-pioglitazone-safeguard-patients-of-lichen-planus-against-homocysteine-induced-accelerated-cardiovascular-aging-and-reduced-myocardial-performance-a-systematic-review
https://pubmed.ncbi.nlm.nih.gov/33527053/
6. 2021
Results serum homocysteine was significantly higher in patients with LP than controls.
Conclusion Serum homocysteine could be reliable predictors of subclinical atherosclerosis in LP.
Evaluation of carotid intima-media thickness and serum homocysteine level as markers of subclinical atherosclerosis in lichen planus Omar Nouran, El-Barbary Rasha, Maghraby Hala, Alhabibi Alshaymaa M, Abd-Elhafeez Hala Year : 2021 | Volume: 5 | Issue Number: 1 | Page: 78-83
https://www.sjamf.eg.net/article.asp?issn=1110-2381;year=2021;volume=5;issue=1;spage=78;epage=83;aulast=Omar;type=0
oral Lichen planus (5)
1. 2015
in 352 OLP patients were compared with 352 healthy.
We found that 52 (14.8%) OLP patients had abnormally high blood homocysteine level (p < 0.001).
Upon further dividing OLP patients into those with major erosive OLP (MjEOLP; n = 67), minor erosive OLP (n = 202), and nonerosive OLP (NEOLP; n = 83), we found that MjEOLP patients had a significantly higher mean homocysteine level than NEOLP patients (p = 0.035).
We conclude that there is a significant association of abnormally high blood homocysteine level with OLP.
There may be a close relation of high blood homocysteine level to severity of OLP.
Chen HM, Wang YP, Chang JY, Wu YC, Cheng SJ, Sun A. Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B12 and high homocysteine level with oral lichen planus. J Formos Med Assoc. 2015 Feb;114(2):124-9. doi: 10.1016/j.jfma.2014.10.004. Epub 2015 Jan 1. PMID: 25557154.
https://www.sciencedirect.com/science/article/pii/S0929664614002940
2. 2016
Erosive oral lichen planus (EOLP) patients
37 (40.2%) of 92 EOLP patients had an abnormally high blood homocysteine level (> 12.1mM) (p < 0.001).
Hematinic deficiencies and anemia statuses in antigastric parietal cell antibody-positive erosive oral lichen planus patients with desquamative gingivitis Julia Yu-Fong Chang a,b,c , Yi-Ping Wang a,b,c , Yang-Che Wu a,b , Yu-Hsueh Wu a,b , Chih-Huang Tseng a,b , Andy Sun
file:///C:/Users/user/Downloads/hematinic-deficiencies-and-anemia-statuses-in-antigastric-parietal-cell-antibody-positive-erosive-oral-lichen-planus-patients-with-desquamative-gingivitis.pdf
https://pubmed.ncbi.nlm.nih.gov/27511590/
3. 2017
30 patients with cutaneous-oral lichen planus.
11 patients (36.66%) in the cutaneous-oral lichen planus group had abnormally high blood homocysteine level (P = 0.001).
Rahmatpour Rokni, G., Heydari, F., Golpour, M., Yazdani, J., & Heidari Gorji, A. M. (2017). Evaluation of Serum Homocysteine Levels in Patients with Cutaneous-Oral Lichen Planus and Psoriasis Patients. Galen Medical Journal, 6(3), 226-232. https://doi.org/10.31661/gmj.v6i3.749
https://gmj.ir/index.php/gmj/article/view/749
4. - 2018
14.8% of 352 OLP patients have abnormally high serum homocysteine level.
Therefore, it is very important to examine homocysteine levels in OLP patients before starting the treatments for OLP patients.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A. Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. J Formos Med Assoc. 2018 Sep;117(9):756-765. doi: 10.1016/j.jfma.2018.01.021. Epub 2018 Feb 19. PMID: 29472048.
https://pubmed.ncbi.nlm.nih.gov/29472048/
5. 2021
increased levels of homocysteine, have been reported in OLP patients
Gholizadeh N, Sheykhbahaei N. Micronutrients Profile in Oral Lichen Planus: a Review Literature. Biol Trace Elem Res. 2021 Mar;199(3):912-924. doi: 10.1007/s12011-020-02221-9. Epub 2020 Jun 12. PMID: 32533293.
https://pubmed.ncbi.nlm.nih.gov/32533293/
11 μελέτες αναφέρουν ότι ένα σημαντικό ποσοστό ασθενών με ομαλό λειχήνα δέρματος και στόματος έχουν ασυνήθιστα υψηλά επίπεδα ομοκυστεΐνης στο αίμα.
Επίσης, ίσως υπάρχει στενή σχέση και στην σοβαρότητα της νόσου διότι μία μελέτη ανέφερε ότι όσο υψηλότερα ήταν τα επίπεδα της ομο, τόσο πιο σοβαρότερη η νόσος.
Serum homocysteine could be reliable predictors of subclinical atherosclerosis in LP (, besides b12 def)
Hcy
Α. ΑΣΥΝΗΘΙΣΤΑ ΥΨΗΛΑ: ομαλός λειχήνας δέρματος, ομαλός λειχηνας στόματος, (6+5=11)
Lichen planus (6)
1. 2014
Serum homocysteine were significantly higher in lichen planus patients than controls (P < 0.001).
Saleh N, Samir N, Megahed H, Farid E. Homocysteine and other cardiovascular risk factors in patients with lichen planus. J Eur Acad Dermatol Venereol. 2014 Nov;28(11):1507-13. doi: 10.1111/jdv.12329. Epub 2013 Dec 12. PMID: 24330130.
https://pubmed.ncbi.nlm.nih.gov/24330130/
2. 2017
This hospital-based case-control study included 110 patients with LP: 70 with cutaneous LP (CLP) and 40 with oral LP (OLP).
There were significantly higher prevalence of higher Hcy, among patients' groups.
Rashed L, Abdel Hay R, AlKaffas M, Ali S, Kadry D, Abdallah S. Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus. J Oral Pathol Med. 2017 Nov;46(10):1023-1029. doi: 10.1111/jop.12588. Epub 2017 May 25. PMID: 28463405.
https://pubmed.ncbi.nlm.nih.gov/28463405/
3. 2019
Significantly increased blood plasma levels of HC,
Melnyk TV, Bondar SA. The role of homocysteine and other endogenous intoxication markers in the pathogenesis of lichen planus. Arch Balk Med Union. 2019;54(3):503-507
https://umbalk.org/the-role-of-homocysteine-and-other-endogenous-intoxication-markers-in-the-pathogenesis-of-lichen-planus/
4. a positive correlation was observed between lichen planus and increased serum homocysteine levels.
Nasiri S, Sadeghzadeh-Bazargan A, Robati RM, Haghighatkhah HR, Younespour S. Subclinical atherosclerosis and cardiovascular markers in patients with lichen planus: A case–control study. Indian J Dermatol Venereol Leprol 2019;85:138-144
https://ijdvl.com/subclinical-atherosclerosis-and-cardiovascular-markers-in-patients-with-lichen-planus-a-case-control-study/
https://pubmed.ncbi.nlm.nih.gov/30632483/
5. 2020
High homocysteine levels in lichen planus play a significant role in modifying the arteries and leading to their dysfunction
Balani P, Lopez A R, Nobleza C N, et al. (December 30, 2020) Can Pioglitazone Safeguard Patients of Lichen Planus Against Homocysteine Induced Accelerated Cardiovascular Aging and Reduced Myocardial Performance: A Systematic Review. Cureus 12(12): e12372. doi:10.7759/cureus.12372
https://www.cureus.com/articles/45427-can-pioglitazone-safeguard-patients-of-lichen-planus-against-homocysteine-induced-accelerated-cardiovascular-aging-and-reduced-myocardial-performance-a-systematic-review
https://pubmed.ncbi.nlm.nih.gov/33527053/
6. 2021
Results serum homocysteine was significantly higher in patients with LP than controls.
Conclusion Serum homocysteine could be reliable predictors of subclinical atherosclerosis in LP.
Evaluation of carotid intima-media thickness and serum homocysteine level as markers of subclinical atherosclerosis in lichen planus Omar Nouran, El-Barbary Rasha, Maghraby Hala, Alhabibi Alshaymaa M, Abd-Elhafeez Hala Year : 2021 | Volume: 5 | Issue Number: 1 | Page: 78-83
https://www.sjamf.eg.net/article.asp?issn=1110-2381;year=2021;volume=5;issue=1;spage=78;epage=83;aulast=Omar;type=0
oral Lichen planus (5)
1. 2015
in 352 OLP patients were compared with 352 healthy.
We found that 52 (14.8%) OLP patients had abnormally high blood homocysteine level (p < 0.001).
Upon further dividing OLP patients into those with major erosive OLP (MjEOLP; n = 67), minor erosive OLP (n = 202), and nonerosive OLP (NEOLP; n = 83), we found that MjEOLP patients had a significantly higher mean homocysteine level than NEOLP patients (p = 0.035).
We conclude that there is a significant association of abnormally high blood homocysteine level with OLP.
There may be a close relation of high blood homocysteine level to severity of OLP.
Chen HM, Wang YP, Chang JY, Wu YC, Cheng SJ, Sun A. Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B12 and high homocysteine level with oral lichen planus. J Formos Med Assoc. 2015 Feb;114(2):124-9. doi: 10.1016/j.jfma.2014.10.004. Epub 2015 Jan 1. PMID: 25557154.
https://www.sciencedirect.com/science/article/pii/S0929664614002940
2. 2016
Erosive oral lichen planus (EOLP) patients
37 (40.2%) of 92 EOLP patients had an abnormally high blood homocysteine level (> 12.1mM) (p < 0.001).
Hematinic deficiencies and anemia statuses in antigastric parietal cell antibody-positive erosive oral lichen planus patients with desquamative gingivitis Julia Yu-Fong Chang a,b,c , Yi-Ping Wang a,b,c , Yang-Che Wu a,b , Yu-Hsueh Wu a,b , Chih-Huang Tseng a,b , Andy Sun
file:///C:/Users/user/Downloads/hematinic-deficiencies-and-anemia-statuses-in-antigastric-parietal-cell-antibody-positive-erosive-oral-lichen-planus-patients-with-desquamative-gingivitis.pdf
https://pubmed.ncbi.nlm.nih.gov/27511590/
3. 2017
30 patients with cutaneous-oral lichen planus.
11 patients (36.66%) in the cutaneous-oral lichen planus group had abnormally high blood homocysteine level (P = 0.001).
Rahmatpour Rokni, G., Heydari, F., Golpour, M., Yazdani, J., & Heidari Gorji, A. M. (2017). Evaluation of Serum Homocysteine Levels in Patients with Cutaneous-Oral Lichen Planus and Psoriasis Patients. Galen Medical Journal, 6(3), 226-232. https://doi.org/10.31661/gmj.v6i3.749
https://gmj.ir/index.php/gmj/article/view/749
4. - 2018
14.8% of 352 OLP patients have abnormally high serum homocysteine level.
Therefore, it is very important to examine homocysteine levels in OLP patients before starting the treatments for OLP patients.
Chiang CP, Yu-Fong Chang J, Wang YP, Wu YH, Lu SY, Sun A. Oral lichen planus - Differential diagnoses, serum autoantibodies, hematinic deficiencies, and management. J Formos Med Assoc. 2018 Sep;117(9):756-765. doi: 10.1016/j.jfma.2018.01.021. Epub 2018 Feb 19. PMID: 29472048.
https://pubmed.ncbi.nlm.nih.gov/29472048/
5. 2021
increased levels of homocysteine, have been reported in OLP patients
Gholizadeh N, Sheykhbahaei N. Micronutrients Profile in Oral Lichen Planus: a Review Literature. Biol Trace Elem Res. 2021 Mar;199(3):912-924. doi: 10.1007/s12011-020-02221-9. Epub 2020 Jun 12. PMID: 32533293.
https://pubmed.ncbi.nlm.nih.gov/32533293/
